Styrene → Ethyl 2-phenylcyclopropane-1-carboxylate

HRID 247735ノート

反応式

HRID 247735 の反応式
[CH2:1]=[CH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[N+](=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[N-]>C(Cl)Cl>[C:3]1([CH:2]2[CH2:1][CH:11]2[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 7501Styrene2 回HCID 12192Ethyl diazoacetate2 回

生成物 1

HCID 316914Ethyl 2-phenylcyclopropane-1-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of CH2Cl2 (12.5 mL), styrene (12 5 mL) and ethyl diazoacetate (0.25 g, 2.19 mmol) was added slowly dropwise at ambient temperature to a stirred slurry of Rh-PFIEP[SO3H] (1.0 g, 0.387 mmol, prepared as described above), styrene (2.5 mL) and CH2Cl2 (2.5 mL). Gas evolution ceased about 1 hour after the addition of the ethyl diazoacetate solution was complete. The resulting slurry was stirred for 24 hours and then allowed to settle. The solution was removed, the resulting resin was washed with 3.0 mL of CH2Cl2. The solution and the wash were combined and analyzed for cyclopropane products. Yield (based on ethyl diazoacetate): 73.9%.

後処理

  1. customThe solution was removed
  2. washthe resulting resin was washed with 3.0 mL of CH2Cl2
  3. customYield (based on ethyl diazoacetate)

出典と根拠

ORDレコード
ord-137bc18394124147bbbd48a0e5264ee2
出典データセット
uspto-grants-1987_11
特許番号
US04709085

反応ノート

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