Acetic Anhydride → N-(4-Pyridinylmethyl)acetamide

HRID 247925ノート

反応式

HRID 247925 の反応式
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>CN(C)C1C=CN=CC=1.N1C=CC=CC=1>[N:6]1[CH:7]=[CH:8][C:3]([CH2:2][NH:1][C:9](=[O:11])[CH3:10])=[CH:4][CH:5]=1

参加物

5

反応物 2

HCID 7918Acetic AnhydrideHCID 773174-Pyridinemethanamine

生成物 1

HCID 289830N-(4-Pyridinylmethyl)acetamide

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 1049Pyridine溶媒

実験手順

The title compound is prepared by the procedure of Example 12 using 25 g of 4-(aminomethyl)pyridine, 25.1 ml of acetic anhydride, 2.26 g of 4-dimethylaminopyridine, 80 ml of pyridine and stirring at room temperature for 68 hours. The residue is purified by column chromatography (silica gel:20% methyl alcohol/ethyl acetate) to give 3.82 g of desired product as orange crystals.

後処理

  1. customThe residue is purified by column chromatography (silica gel:20% methyl alcohol/ethyl acetate)

出典と根拠

ORDレコード
ord-722f0a034b5d44fb99562cef7d2dffdb
出典データセット
uspto-grants-1993_05
特許番号
US05208247

反応ノート

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