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Pyridine → 1-(Bromomethyl)-4-(tetradecyloxy)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Phosphorus tribromide | HCID 24614 | — |
| 反応物 | 4-Tetradecyloxybenzyl alcohol | HCID 10087384 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(Bromomethyl)-4-(tetradecyloxy)benzene | HCID 10022840 | 88.7% |
反応手順
To a room temperature slurry of 2.5 g of product from Example 19, 10 ml of acetonitrile and 0.339 g of pyridine is added dropwise, over 3 minutes, 2.11 g of phosphorus tribromide. The reaction is stirred at room temperature for 1 hour, diluted with methylene chloride and concentrated in vacuo. The residue is dissolved in methylene chloride, filtered through a silica gel pad and concentrated in vacuo to give 2.65 g of the desired product as pale yellow crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05208247 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-4d4f05d0770d4ec2b0f3bf0f9e2a5dfb |
| 出典メモ | uspto-grants-1993_05 |