Protocatechuic Acid → Methyl 3,4-Dihydroxybenzoate

HRID 248008

反応式

HRID 248008 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].[CH3:12]O.S(=O)(=O)(O)O>O>[CH3:12][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([OH:11])=[C:2]([OH:1])[CH:3]=1

参加物

5

反応物 3

HCID 72Protocatechuic AcidHCID 887MethanolHCID 1118Sulfuric Acid

生成物 1

HCID 287064Methyl 3,4-Dihydroxybenzoate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 100 g of 3,4-dihydroxy benzoic acid, 600 ml methyl alcohol and 10 ml of concentrated sulfuric acid is heated at reflux for 18 hours. The reaction mixture is cooled to room temperature, poured into water and extracted with methylene chloride. The organic layer is washed with saturated sodium bicarbonate and sodium chloride, dried and concentrated in vacuo to give 50.6 g of the desired product.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 18 hours
  3. extractionextracted with methylene chloride
  4. washThe organic layer is washed with saturated sodium bicarbonate and sodium chloride
  5. customdried
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0728eac988504734b7fcf8ac9919ae17
出典データセット
uspto-grants-1993_05
特許番号
US05208247

関連ノート

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