Acetone → Methyl 4-(t-butylacetylthio)phenylacetate

関与物質

役割	名称	HCID	仕込み量
反応物	Acetone	HCID 180	—
反応物	Potassium Iodide	HCID 4875	—
反応物	Potassium Carbonate	HCID 11430	—
反応物	tert-Butyl bromoacetate	HCID 79177	—
反応物	Methyl 2-(4-mercaptophenyl)acetate	HCID 14033178	—
生成物	Methyl 4-(t-butylacetylthio)phenylacetate	HCID 19764532	—

反応手順

Dissolve methyl 4-mercaptophenylacetate (16.4 g, 90.3 mmol) in acetone (300 mL). Add potassium carbonate (13.7 g, 99.3 mmol), potassium iodide (1.47 g, 9.03 mmol) and t-butylbromoacetate (16 mL, 99.3 mmol). Heat at reflux for 20 hours then remove 200 mL of acetone in vacuo. Dilute the residue with ethyl ether (500 mL), wash with water (2×300 mL) and brine (300 mL). Dry (MgSO4) and evaporate the solvent in vacuo. Purify by flash chromatography to give the title compound.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US05208240
出典データセット	uspto-grants-1993_05
ORD ID	ord-6f218fe89b5c4aafaca031e3af768e57
出典メモ	uspto-grants-1993_05