N-bromobutanimide → 1-(Bromomethyl)-2-chloro-4-iodobenzene
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([I:9])[CH:5]=[CH:6][C:7]=1[CH3:8].[Br:10]N1C(=O)CCC1=O>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C(Cl)(Cl)(Cl)Cl>[Br:10][CH2:8][C:7]1[CH:6]=[CH:5][C:4]([I:9])=[CH:3][C:2]=1[Cl:1]参加物
5
実験手順
A mixture of 3-chloro-4-methyliodobenzene (9.0 g), N-bromosuccinimide (8.5 g), benzoyl peroxide (0.3 g) and carbon tetrachloride (80 ml) was stirred and heated to reflux for 3 hours. The mixture was cooled to ambient temperature and filtered. The filtrate was evaporated to give 4-bromomethyl-3-chloroiodobenzene (11 g) which was used without further purification.
後処理
- temperatureheated
- temperatureto reflux for 3 hours
- filtrationfiltered
- customThe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-935f0674609840a5b887ec8d5a6be8ee
- 出典データセット
- uspto-grants-1993_05
- 特許番号
- US05208259
反応ノート
読み込み中…