Ammonia → 2,2-Difluoro-1-Methylcyclopropanecarboxamide

HRID 248221

反応式

HRID 248221 の反応式
[NH3:1].[F:2][C:3]1([F:10])[CH2:5][C:4]1([CH3:9])[C:6](Cl)=[O:7]>O1CCOCC1>[F:2][C:3]1([F:10])[CH2:5][C:4]1([C:6]([NH2:1])=[O:7])[CH3:9]

参加物

4

反応物 2

HCID 222AmmoniaHCID 146952322,2-Difluoro-1-methylcyclopropane-1-carbonyl chloride

生成物 1

HCID 146952362,2-Difluoro-1-Methylcyclopropanecarboxamide収率 81%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Gaseous ammonia is passed for 90 minutes into a stirred solution of 15.45 g (0.1 mol) of 2,2-difluoro-1-methyl-cyclopropane-carbonyl chloride in 80 ml of dioxane at 20° to 30° C. The resultant suspension is then evaporated to dryness under a water pump vacuum. The residue remaining is stirred with 50 ml of water, filtered off with suction and dried. In this manner, 11 g (81% of theory) of 2,2-difluoro-1-methyl-cyclopropyl-carboxamide in form of a solid substance of melting point 125°-127° C. are obtained.

後処理

  1. customThe resultant suspension is then evaporated to dryness under a water pump vacuum
  2. filtrationfiltered off with suction
  3. customdried

出典と根拠

ORDレコード
ord-c4c078dec5e3494b98b6169bc5475e93
出典データセット
uspto-grants-1993_05
特許番号
US05208388

関連ノート

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