Trimethyl orthovalerate → 2-butyl-1H-thieno[3,4-d]imidazole
反応式
[NH2:1][C:2]1[C:6]([NH2:7])=[CH:5][S:4][CH:3]=1.[C:8](OC)(OC)(OC)[CH2:9][CH2:10][CH2:11][CH3:12].C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1>C(O)C>[CH2:9]([C:8]1[NH:1][C:2]2=[CH:3][S:4][CH:5]=[C:6]2[N:7]=1)[CH2:10][CH2:11][CH3:12]参加物
5
実験手順
To a solution of 3,4-diaminothiophene (156 mg) in ethanol (10 ml) was added trimethyl orthovalerate (0.29 ml) and pyridinium p-toluenesulfonate (4 mg). The mixture was refluxed for one hour and concentrated in vacuo. The residue was purified by preparative thin layer chromatography on silica gel developed by ethyl acetate to give 2-butyl-1H-thieno[3,4-d]imidazole (155 mg) as crystals.
後処理
- temperatureThe mixture was refluxed for one hour
- concentrationconcentrated in vacuo
- customThe residue was purified by preparative thin layer chromatography on silica gel
出典と根拠
- ORDレコード
- ord-354f919044724ce2b749849551db4a26
- 出典データセット
- uspto-grants-1993_05
- 特許番号
- US05210092
反応ノート
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