7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 14839376、化合物

HRID 248485ノート

反応式

HRID 248485 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]2[CH2:12][NH:11][CH2:10][CH2:9][NH:8]2)[S:5][CH:6]=1.Cl[C:14]1[CH:23]=[C:22]2[C:17]([C:18](=[O:29])[C:19]([C:26]([OH:28])=[O:27])=[CH:20][N:21]2[CH2:24][CH3:25])=[CH:16][C:15]=1[F:30]>N1C=CC=CC=1>[CH2:24]([N:21]1[C:22]2[C:17](=[CH:16][C:15]([F:30])=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH:7]([C:4]4[S:5][CH:6]=[C:2]([CH3:1])[CH:3]=4)[CH2:12]3)[CH:23]=2)[C:18](=[O:29])[C:19]([C:26]([OH:28])=[O:27])=[CH:20]1)[CH3:25]

参加物

4

反応物 2

HCID 4831697-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 197636002-(4-Methylthiophen-2-yl)piperazine

生成物 1

HCID 14839376HCID 14839376、化合物収率 24.1%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 10.92 g of 2-(4-methyl-2-thienyl)piperazine and 5.38 g of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid in 30 ml of pyridine was heated at reflux under argon for 18 hours, then allowed to cool and the solvent removed. The residue was triturated with methanol and ether, then filtered and dried, giving 2 g of the desired product, mp 230° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux under argon for 18 hours
  3. temperatureto cool
  4. customthe solvent removed
  5. customThe residue was triturated with methanol and ether
  6. filtrationfiltered
  7. customdried

出典と根拠

ORDレコード
ord-da6a6a0cff9944c4bc7926920cd59716
出典データセット
uspto-grants-1993_05
特許番号
US05210193

反応ノート

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