Hydrochloric Acid → Acetophenone, 2',4'-dichloro-5'-fluoro-

HRID 248499

反応式

HRID 248499 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[C:4]([Cl:9])[CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[C:14](OC(=O)C)(=[O:16])[CH3:15].Cl>>[C:14]([C:7]1[C:2]([Cl:1])=[CH:3][C:4]([Cl:9])=[C:5]([F:8])[CH:6]=1)(=[O:16])[CH3:15]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 123112Benzene, 2,4-dichloro-1-fluoro-HCID 6451240Aluminum(III) Chloride

生成物 1

HCID 727250Acetophenone, 2',4'-dichloro-5'-fluoro-

反応条件

温度
80 °C

実験手順

A mixture of 229.6 g of 1,3-dichloro-4-fluorobenzene and 205.34 g of aluminum chloride was heated at 80° C. A 56 g portion of acetic anhydride was added dropwise over 2 hours, then the reaction ws heated at 100° C. for 8 hours, poured onto a mixture of concentrated hydrochloric acid and ice and extracted several times with ether. The ether extracts were combined, washed with water, dried and the solvents evaporated. The solid was purified by vacuum distillation, giving 156.63 g of 6-acetyl-1,3-dichloro-4-fluorobenzene.

後処理

  1. temperaturethe reaction ws heated at 100° C. for 8 hours
  2. extractionextracted several times with ether
  3. washwashed with water
  4. customdried
  5. customthe solvents evaporated
  6. distillationThe solid was purified by vacuum distillation

出典と根拠

ORDレコード
ord-37d187f7d13144d49ee81d90538374b3
出典データセット
uspto-grants-1993_05
特許番号
US05210193

関連ノート

読み込み中…