関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Benzene, 2,4-dichloro-1-fluoro- | HCID 123112 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 生成物 | Acetophenone, 2',4'-dichloro-5'-fluoro- | HCID 727250 | — |
反応手順
A mixture of 229.6 g of 1,3-dichloro-4-fluorobenzene and 205.34 g of aluminum chloride was heated at 80° C. A 56 g portion of acetic anhydride was added dropwise over 2 hours, then the reaction ws heated at 100° C. for 8 hours, poured onto a mixture of concentrated hydrochloric acid and ice and extracted several times with ether. The ether extracts were combined, washed with water, dried and the solvents evaporated. The solid was purified by vacuum distillation, giving 156.63 g of 6-acetyl-1,3-dichloro-4-fluorobenzene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05210193 |
|---|
| 出典データセット | uspto-grants-1993_05 |
|---|
| ORD ID | ord-37d187f7d13144d49ee81d90538374b3 |
|---|
| 出典メモ | uspto-grants-1993_05 |
|---|
