反应详情

温度

80 °C

A mixture of 229.6 g of 1,3-dichloro-4-fluorobenzene and 205.34 g of aluminum chloride was heated at 80° C. A 56 g portion of acetic anhydride was added dropwise over 2 hours, then the reaction ws heated at 100° C. for 8 hours, poured onto a mixture of concentrated hydrochloric acid and ice and extracted several times with ether. The ether extracts were combined, washed with water, dried and the solvents evaporated. The solid was purified by vacuum distillation, giving 156.63 g of 6-acetyl-1,3-dichloro-4-fluorobenzene.

1. temperaturethe reaction ws heated at 100° C. for 8 hours
2. extractionextracted several times with ether
3. washwashed with water
4. customdried
5. customthe solvents evaporated
6. distillationThe solid was purified by vacuum distillation