Dichloromethane → HCID 178485780、化合物

反応式

C1(=O)[N:5]([CH2:6][C:7]([N:9]([C:11]2[CH:16]=[CH:15][C:14]([NH:17]/[C:18](=[C:25]3\[C:26](=[O:37])[NH:27][C:28]4[C:33]\3=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][CH:29]=4)/[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:13][CH:12]=2)[CH3:10])=[O:8])C(=O)C2=CC=CC=C12.ClCCl.O.NN>C(O)C>[NH2:5][CH2:6][C:7]([N:9]([C:11]1[CH:16]=[CH:15][C:14]([NH:17]/[C:18](=[C:25]2\[C:26](=[O:37])[NH:27][C:28]3[C:33]\2=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][CH:29]=3)/[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:13][CH:12]=1)[CH3:10])=[O:8]

参加物

反応条件

温度: 50 °C

実験手順

287 mg (0.5 mmol) of (Z)-3-{1-[4-(N-phthalimidomethylcarbonyl-N-methylamino)phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone are suspended in 20 ml of ethanol and 20 ml of dichloromethane and after the addition of 0.3 ml of 80% hydrazine hydrate solution stirred for 18 hours at 50° C. The mixture is then cooled to ambient temperature, the insoluble matter is suction filtered and the mother liquor is concentrated by evaporation. The residue is chromatographed on silica gel (dichloromethane/methanol/ammonia=92:8:0.8) and the product is again triturated with methanol, suction filtered and dried.