Citric Acid → 3-Nitro-4-pyrrolidin-1-ylbenzoic acid
反応式
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[CH2:14]([N:16](CC)[CH2:17][CH3:18])[CH3:15].N1CCCC1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>C1(C)C(C)=CC=CC=1>[N+:11]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:2]=1[N:16]1[CH2:17][CH2:18][CH2:15][CH2:14]1)[C:6]([OH:8])=[O:7])([O-:13])=[O:12]参加物
6
実験手順
4-Chloro-3-nitrobenzoic acid (5.0 g) is suspended in xylene (50 ml), and thereto are added triethylamine (2.5 g) and pyrrolidine (2.0 g), and the mixture is refluxed for 2 hours. To the reaction mixture is added 10% aqueous citric acid solution, and the precipitated crystals are separated by filtration, washed with water and dried to give 3-nitro-4-(1-pyrrolidinyl)benzoic acid (5.6 g).
後処理
- temperaturethe mixture is refluxed for 2 hours
- customthe precipitated crystals are separated by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-0ed6e5a25ca84c44ba04df62d25a0ae8
- 出典データセット
- uspto-grants-1993_05
- 特許番号
- US05210266
反応ノート
読み込み中…