2-Amino-5-methylthiazole → HCID 22401741、化合物

HRID 248881

反応式

HRID 248881 の反応式
[Br:1][CH2:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)=[O:4].[CH3:10][C:11]1[S:15][C:14]([NH2:16])=[N:13][CH:12]=1>C(#N)C>[BrH:1].[NH:16]=[C:14]1[N:13]([CH2:2][C:3]([C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)=[O:4])[CH:12]=[C:11]([CH3:10])[S:15]1

参加物

4

反応物 2

HCID 3517702-Amino-5-methylthiazoleHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

生成物 1

HCID 22401741HCID 22401741、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 51 parts of 2-bromo-1-(2-thienyl)ethanone, 28.5 parts of 5-methyl-2-thiazolamine and 240 parts of acetonitrile was stirred for 1 hour while heating on a waterbath. After cooling, the precipitate was filtered off, washed with ethanol and dried in vacuo, yielding 54 parts of 2-(2,3-dihydro-2-imino-5-methyl-3-thiazolyl)-1-(2-thienyl)ethanone hydrobromide; mp. 207.5°-208° C. (interm. 56).

後処理

  1. temperaturewhile heating on a waterbath
  2. temperatureAfter cooling
  3. filtrationthe precipitate was filtered off
  4. washwashed with ethanol
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-ada5bbdbe62d4290905705d5d577da87
出典データセット
uspto-grants-1993_05
特許番号
US05212192

関連ノート

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