Methanamine, hydrochloride (1:1) → HCID 178485779、化合物

HRID 24889

反応式

HRID 24889 の反応式
[C:1]([CH2:4][N:5]([C:10]1[CH:15]=[CH:14][C:13]([NH:16]/[C:17](=[C:24]2\[C:25](=[O:33])[NH:26][C:27]3[C:32]\2=[CH:31][CH:30]=[CH:29][CH:28]=3)/[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)[S:6]([CH3:9])(=[O:8])=[O:7])(O)=[O:2].[Cl-].C[NH3+].C1C=CC2N(O)N=[N:43][C:41]=2C=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(C(C)C)C(C)C)C>CN(C=O)C>[CH3:41][NH:43][C:1]([CH2:4][N:5]([C:10]1[CH:11]=[CH:12][C:13]([NH:16]/[C:17](=[C:24]2\[C:25](=[O:33])[NH:26][C:27]3[C:32]\2=[CH:31][CH:30]=[CH:29][CH:28]=3)/[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:14][CH:15]=1)[S:6]([CH3:9])(=[O:7])=[O:8])=[O:2]

参加物

7

反応物 5

HCID 11637Methanamine, hydrochloride (1:1)HCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 178505129HCID 178505129、化合物

生成物 1

HCID 178485779HCID 178485779、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Prepared analogously to Example 18 from (Z)-3-{1-[4-(N-carboxymethyl-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-2-indolinone, methylammonium chloride, HOBt, TBTU and N-ethyl-N,N-diisopropylamine in DMF.

出典と根拠

ORDレコード
ord-f7272e6a784d4b67bca9b160d4bd8cb0
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

関連ノート

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