Thionyl Chloride → 3-(1-Adamantyl)-4-methoxybenzoyl chloride

HRID 249024ノート

反応式

HRID 249024 の反応式
[C:1]12([C:11]3[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[C:14](O)=[O:15])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.S(Cl)([Cl:24])=O>>[C:1]12([C:11]3[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[C:14]([Cl:24])=[O:15])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 52965033-(1-Adamantyl)-4-methoxybenzoic acid

生成物 1

HCID 108044973-(1-Adamantyl)-4-methoxybenzoyl chloride収率 100%

実験手順

In a round bottom flask, there are introduced 200 ml of thionyl chloride and there are then added, in small fractions, 35 g (122 mmoles) of the acid obtained in stage (a), above. The reaction mixture is heated to reflux until the emission of gases ceases. The reaction mixture is evaporated to dryness, taken up in 100 ml of anhydrous benzene and again evaporated to dryness, yielding 37 g of the expected product (100% yield) having a melting point of 153°-154° C.

後処理

  1. temperatureThe reaction mixture is heated
  2. temperatureto reflux until the emission of gases ceases
  3. customThe reaction mixture is evaporated to dryness
  4. customagain evaporated to dryness

出典と根拠

ORDレコード
ord-19110497a281468ea9a9a7cea488f338
出典データセット
uspto-grants-1993_05
特許番号
US05212203

反応ノート

読み込み中…