Hydrochloric Acid → 4-Propylhept-1-en-4-ol

113 g of 4-heptanone in 1000 ml of dry diethyl ether was slowly added to a solution of allylmagnesium bromide, prepared from 36.5 g of Mg and 178 g of allyl bromide in 500 ml dry diethyl ether. After the addition the mixture was refluxed for 10 hrs. The reaction mixture was poured on a mixture of 150 g ice, 450 ml of 20% NH4Cl and 350 ml of 5M HCl. The ether phase was separated and the water phase extracted with diethyl ether (3×100 ml). The combined organic phases were then washed with a Na2CO3 -solution and water, dried with Na2SO4 and evaporated. The residue was distilled. Yield: 142 g (b.p. 38°-40° C./0.1 torr)

1. additionAfter the addition the mixture
2. temperaturewas refluxed for 10 hrs
3. customThe ether phase was separated
4. extractionthe water phase extracted with diethyl ether (3×100 ml)
5. washThe combined organic phases were then washed with a Na2CO3 -solution and water
6. dry with materialdried with Na2SO4
7. customevaporated
8. distillationThe residue was distilled

ORDレコード

ord-0e01eb8edbf44983986d69a0faa08a22

出典データセット

uspto-grants-1993_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05212305