Water → 4-Amino-pyrido[2,3-e]pyrimidin-2-one

HRID 249078

反応式

HRID 249078 の反応式
[NH2:1][C:2]1[C:3]([C:8]#[N:9])=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:10][C:11](N)=[O:12].O>C(OCCOCCO)C>[NH2:9][C:8]1[C:3]2[N:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:11](=[O:12])[N:10]=1

参加物

5

反応物 3

HCID 962WaterHCID 1176UreaHCID 5770153-Aminopyridine-2-carbonitrile

生成物 1

HCID 193668794-Amino-pyrido[2,3-e]pyrimidin-2-one

試薬・触媒・溶媒 1

HCID 8146Diethylene Glycol Monoethyl Ether溶媒

反応条件

温度
205 °C

実験手順

A slurry of 3-Amino-2-cyanopyridine (200 mg) and urea (400 mg) in 2-(2-ethoxyethoxy)ethanol (0.5 mL) was gradually heated to about 205° C., and maintained at 205° C. for 10 min. Heating was ceased and 6 mL of hot water was carefully added while shaking the mixture. The mixture was vacuum filtered to collect the precipitate. The precipitate was washed with water and ethyl acetate and allowed to dry to yield 4-Amino-pyrido[2,3-e]pyrimidin-2-one as a light yellow solid, m.p. >300° C.

後処理

  1. temperatureHeating
  2. filtrationfiltered
  3. customto collect the precipitate
  4. washThe precipitate was washed with water and ethyl acetate
  5. customto dry

出典と根拠

ORDレコード
ord-8c8abec0a7934af8a15f606f2ba90a6a
出典データセット
uspto-grants-1993_05
特許番号
US05212310

関連ノート

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