Phenacyl bromide → HCID 135418313、化合物

HRID 249079

反応式

HRID 249079 の反応式
[NH2:1][C:2]1[C:7]2[N:8]=[CH:9][CH:10]=[CH:11][C:6]=2[NH:5][C:4](=[O:12])[N:3]=1.Br[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O>CN(C)C=O>[C:17]1([C:15]2[N:1]=[C:2]3[C:7]4[N:8]=[CH:9][CH:10]=[CH:11][C:6]=4[NH:5][C:4](=[O:12])[N:3]3[CH:14]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 6259Phenacyl bromideHCID 193668794-Amino-pyrido[2,3-e]pyrimidin-2-one

生成物 1

HCID 135418313HCID 135418313、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
150 °C

実験手順

A mixture of 4-Amino-pyrido[2,3-e]pyrimidin-2-one (95 mg) and αbromo-acetophenone (117 mg) in 4 mL of dimethylformamide (DMF) was heated at about 150° C. for 20 min. The reaction mixture was concentrated in vacuo and the residue was subjected to flash chromatography on silica gel with 10% methanol/methylene chloride as the eluent to afford 2-Phenylimidazo[1,2-c]pyrido[2,3-e]pyrimidin-5(6H)-one, (Compound 15), m.p. 329°-330° C.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-320e1807743244cdbe57665e69f96157
出典データセット
uspto-grants-1993_05
特許番号
US05212310

関連ノート

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