1-(2-Methyl-1-propenyl)-3-nitrobenzene → 3-Isobutylaniline
反応式
[CH3:1][C:2]([CH3:13])=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-])=O)[CH:5]=1>CO.Cl.[Pd]>[CH2:3]([C:4]1[CH:5]=[C:6]([NH2:10])[CH:7]=[CH:8][CH:9]=1)[CH:2]([CH3:13])[CH3:1]参加物
5
反応条件
- 温度
- 25 °C
実験手順
To a solution of 1-(2-methyl-1-propenyl)-3-nitrobenzene (4.57 g) in a mixture of methanol (50 ml) and 6N hydrochloric acid (14 ml) was added 10% palladium on activated carbon (1 g), and the mixture was stirred under hydrogen atmosphere (3 atm) at 25° C. for 3 hours. The catalyst was filtered off, and the filtrate was evaporated. The residue was poured into a mixture of ethyl acetate and aqueous sodium bicarbonate. The organic layer was separated, washed with water and brine, and dried over magnesium sulfate. Evaporation of the solvent gave 3-isobutylphenylamine (3.98 g) as a brown oil.
後処理
- filtrationThe catalyst was filtered off
- customthe filtrate was evaporated
- additionThe residue was poured into a mixture of ethyl acetate and aqueous sodium bicarbonate
- customThe organic layer was separated
- washwashed with water and brine
- dry with materialdried over magnesium sulfate
- customEvaporation of the solvent
出典と根拠
- ORDレコード
- ord-2564850177c84120a6750dffd2d101d7
- 出典データセット
- uspto-grants-1993_05
- 特許番号
- US05212320
反応ノート
読み込み中…