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1-Hydroxybenzotriazole → HCID 19024865、化合物

HRID 249174
ノート
印刷プレビュー

反応式

HRID 249174 の反応式
Cl.CN(C)CCCN=C=NCC.[C:13]([CH:16]([C:43]1[CH:48]=[CH:47][C:46]([CH2:49][CH:50]([CH3:52])[CH3:51])=[CH:45][CH:44]=1)[O:17][C:18]1[CH:42]=[CH:41][C:21]([C:22]([C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[N:26]([CH2:33][CH2:34][CH2:35][C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH:25]=2)=[O:23])=[CH:20][CH:19]=1)([OH:15])=O.[CH2:53]([C:57]1[CH:63]=[CH:62][C:60]([NH2:61])=[CH:59][CH:58]=1)[CH:54]([CH3:56])[CH3:55].ON1C2C=CC=CC=2N=N1>ClCCl>[CH2:49]([C:46]1[CH:47]=[CH:48][C:43]([CH:16]([C:13](=[O:15])[NH:61][C:60]2[CH:62]=[CH:63][C:57]([CH2:53][CH:54]([CH3:56])[CH3:55])=[CH:58][CH:59]=2)[O:17][C:18]2[CH:19]=[CH:20][C:21]([C:22]([C:24]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[N:26]([CH2:33][CH2:34][CH2:35][C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH:25]=3)=[O:23])=[CH:41][CH:42]=2)=[CH:44][CH:45]=1)[CH:50]([CH3:51])[CH3:52]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 757711-HydroxybenzotriazoleHCID 1216274-IsobutylanilineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 19024864HCID 19024864、化合物

生成物 1

HCID 19024865HCID 19024865、化合物収率 97.7%

試薬・触媒・溶媒 1

HCID 6344
Dichloromethane
溶媒

反応条件

温度
25 °C

実験手順

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (30 mg) was added to a mixture of ethyl 4-[3-[4-[(carboxy)(4-isobutylphenyl)methoxy]benzoyl]-indol-1-yl]butyrate (70 mg), 4-isobutylaniline (20 mg) and 1-hydroxybenzotriazole (20 mg) in dichloromethane (3 ml). After stirred at 25° C. for 4 hours, the mixture was partitioned between ethyl acetate and 1N hydrochloric acid. The organic layer was separated, washed with water and brine, and dried over magnesium sulfate. After evaporation of the solvent, the residue was chromatographed on silica gel (5 g) eluting with chloroform to give ethyl 4-[3-[4-[(4-isobutylphenyl)[(4-isobutylphenyl)carbamoyl]methoxy]benzoyl]indol-1-yl]butyrate (85 mg) as an oil.

後処理

  1. customthe mixture was partitioned between ethyl acetate and 1N hydrochloric acid
  2. customThe organic layer was separated
  3. washwashed with water and brine
  4. dry with materialdried over magnesium sulfate
  5. customAfter evaporation of the solvent
  6. customthe residue was chromatographed on silica gel (5 g)
  7. washeluting with chloroform

出典と根拠

ORDレコード
ord-e2326a7dded74f09bdc92435593d449e
出典データセット
uspto-grants-1993_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05212320

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート