Carbon tetrabromide → 1-Bromohexyl-4-isobutylbenzene

HRID 249185

反応式

HRID 249185 の反応式
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11](O)[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].C(Br)(Br)(Br)[Br:19].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[Br:19][CH:11]([C:8]1[CH:9]=[CH:10][C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:6][CH:7]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 109334301-(4-Isobutylphenyl)hexan-1-ol

生成物 1

HCID 109353641-Bromohexyl-4-isobutylbenzene収率 30.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1-(4-isobutylphenyl)hexan-1-ol (9.15 g) and carbon tetrabromide (25.9 g) in tetrahydrofuran (250 ml) was added triphenylphosphine (20.5 g). The mixture was stirred at room temperature for 6 hours. After the white solid was filtered off, the filtrate was evaporated. n-Hexane (300 ml) was added to the residue and the precipitate was filtered off. The filtrate was evaporated and the residual oil was distilled under reduced pressure to give 1-(1-bromohexyl)-4-isobutylbenzene (3.52 g) as a colorless oil.

後処理

  1. filtrationAfter the white solid was filtered off
  2. customthe filtrate was evaporated
  3. additionn-Hexane (300 ml) was added to the residue
  4. filtrationthe precipitate was filtered off
  5. customThe filtrate was evaporated
  6. distillationthe residual oil was distilled under reduced pressure

出典と根拠

ORDレコード
ord-3b17771e21d840159097bddd23cd28db
出典データセット
uspto-grants-1993_05
特許番号
US05212320

関連ノート

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