N-(1-benzylpiperid-4-yl)-N-methylpropionamide → N-Methyl-N-(piperidin-4-yl)propionamide

HRID 249339ノート

反応式

HRID 249339 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1

参加物

4

反応物 1

HCID 19761195N-(1-benzylpiperid-4-yl)-N-methylpropionamide

生成物 1

HCID 19761222N-Methyl-N-(piperidin-4-yl)propionamide収率 60%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

31 g of the amine obtained in Stage B are hydrogenated in 350 ml of ethanol with 1 g of palladium hydroxide at atmospheric pressure and room temperature. The mixture is filtered and evaporated to yield the desired product in the form of an oil.

後処理

  1. filtrationThe mixture is filtered
  2. customevaporated

出典と根拠

ORDレコード
ord-ebdf0bba50384124b7730060a2bd1a56
出典データセット
uspto-grants-1993_05
特許番号
US05214055

反応ノート

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