Benzyl chloroformate → Carbamic acid, (1-acetyl-4-piperidinyl)methyl-, phenylmethyl ester

反応式

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][CH3:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].Cl[C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14]>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10]([CH3:11])[C:13](=[O:14])[O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

参加物

反応物 2

HCID 10387Benzyl chloroformate

HCID 197612651-[4-(Methylamino)piperidin-1-yl]ethan-1-one

生成物 1

HCID 19761266Carbamic acid, (1-acetyl-4-piperidinyl)methyl-, phenylmethyl ester収率 54%

実験手順

The amine obtained in Stage A is treated with benzyl chloroformate in accordance with the process described in Stage B of Example 1 to obtain the desired carbamate.

出典と根拠

ORDレコード: ord-40617e024faa4a47bdb9048f8d9c3a9d
出典データセット: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05214055

反応ノート

読み込み中…