Dimethylamine → N,N-dimethyl-2-(4-nitrophenoxy)ethanamine

HRID 24937ノート

反応式

HRID 24937 の反応式
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1.[CH3:14][NH:15][CH3:16]>CN(C)C=O>[CH3:14][N:15]([CH3:16])[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 674DimethylamineHCID 2359871-(2-Bromoethoxy)-4-nitrobenzene

生成物 1

HCID 887421N,N-dimethyl-2-(4-nitrophenoxy)ethanamine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4.9 g (20 mmol) of 4-(2-bromoethyloxy)-nitrobenzene and 2.7 g (60 mmol) of dimethylamine in 50 ml of dimethylformamide are heated to 100° C. for 24 hours in a bomb tube. After removal of the solvent in vacuo the residue is taken up in water and extracted with dichloromethane. The organic phase is dried and concentrated by evaporation.

後処理

  1. customAfter removal of the solvent in vacuo the residue
  2. extractionextracted with dichloromethane
  3. customThe organic phase is dried
  4. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-a8e4bf5abd1e4934998ac18b605dab70
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

反応ノート

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