2-Propanesulfonyl chloride → Isopropylsulphonic acid-(4-tert.butoxycarbonylamino-phenyl)-amide

HRID 24939

反応式

HRID 24939 の反応式
[CH:1]([S:4](Cl)(=[O:6])=[O:5])([CH3:3])[CH3:2].[C:8]([O:12][C:13]([NH:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1)=[O:14])([CH3:11])([CH3:10])[CH3:9]>N1C=CC=CC=1>[C:8]([O:12][C:13]([NH:15][C:16]1[CH:17]=[CH:18][C:19]([NH:20][S:4]([CH:1]([CH3:3])[CH3:2])(=[O:6])=[O:5])=[CH:21][CH:22]=1)=[O:14])([CH3:11])([CH3:9])[CH3:10]

参加物

4

反応物 2

HCID 824082-Propanesulfonyl chlorideHCID 688611tert-Butyl (4-aminophenyl)carbamate

生成物 1

HCID 22569426Isopropylsulphonic acid-(4-tert.butoxycarbonylamino-phenyl)-amide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

1.2 g (10 mmol) of isopropylsulphonic acid chloride are added dropwise to a solution of 1.0 g (4.8 mmol) of 4-tert.butoxycarbonylamino-aniline in 10 ml of pyridine. The mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is poured onto 150 ml of ice water and then extracted with ethyl acetate. The organic phases are washed with water and freed from solvent. The residue is chromatographed on silica gel (dichloromethane/methanol/NH4OH=19:1:0.1).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic phases are washed with water
  3. customThe residue is chromatographed on silica gel (dichloromethane/methanol/NH4OH=19:1:0.1)

出典と根拠

ORDレコード
ord-da9825c092654534b8c9572e9d0b2491
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

関連ノート

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