Formic Acid → 4-(n-(2-Dimethylaminoethyl)-n-formyl-amino)-nitrobenzene

HRID 24944ノート

反応式

HRID 24944 の反応式
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1.[OH-].[Na+].[CH:18](O)=[O:19]>O>[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][N:5]([C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)[CH:18]=[O:19]

参加物

5

反応物 3

HCID 284Formic AcidHCID 14798Sodium HydroxideHCID 22569398HCID 22569398、化合物

生成物 1

HCID 225694284-(n-(2-Dimethylaminoethyl)-n-formyl-amino)-nitrobenzene

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.4 g (6.7 mmol) of 4-(2-dimethylamino-ethylamino)-nitrobenzene (Example 326a) are refluxed for 4 hours in 20 ml of formic acid. Then the solvent is eliminated in vacuo, the residue taken up in water and combined with 2 N sodium hydroxide solution until an alkaline reaction is obtained. The mixture is extracted with ethyl acetate, the combined organic phases are dried over magnesium sulphate and the solvent is eliminated in vacuo. The product is obtained as an oil.

後処理

  1. customis obtained
  2. extractionThe mixture is extracted with ethyl acetate
  3. dry with materialthe combined organic phases are dried over magnesium sulphate
  4. customThe product is obtained as an oil

出典と根拠

ORDレコード
ord-14638ac4203a46dda21480f2af6d163b
出典データセット
uspto-grants-2005_02
特許番号
US06855710B2

反応ノート

読み込み中…