関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Pyridine, 3-(2-chloroethyl)-, hydrochloride | HCID 199465 | — |
| 生成物 | N-Methyl-2-(pyridin-3-YL)ethanamine | HCID 5152594 | 110.5% |
反応手順
To 32.6 g of 40% aqueous methylamine solution was added 7.48 g (0.042 mole) of 2-(3-pyridyl)ethyl chloride hydrochloride in small portions with stirring. The mixture was transfered to a stainless steel reaction column and heated at an external temperature of 80° C. for 4 hours. After cooling, 3.36 g of NaOH was added with ice-cooling and stirring and the mixture was saturated with sodium chloride and extracted with CH2Cl2. The extract was dried over MgSO4 and the CH2Cl2 was distilled off to give 6.32 g of the title compound in crude form as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05214152 |
|---|
| 出典データセット | uspto-grants-1993_05 |
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| ORD ID | ord-dbb7fe6b4f0c445f834aa9bd274f8366 |
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| 出典メモ | uspto-grants-1993_05 |
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