反应详情

温度

80 °C

To 32.6 g of 40% aqueous methylamine solution was added 7.48 g (0.042 mole) of 2-(3-pyridyl)ethyl chloride hydrochloride in small portions with stirring. The mixture was transfered to a stainless steel reaction column and heated at an external temperature of 80° C. for 4 hours. After cooling, 3.36 g of NaOH was added with ice-cooling and stirring and the mixture was saturated with sodium chloride and extracted with CH2Cl2. The extract was dried over MgSO4 and the CH2Cl2 was distilled off to give 6.32 g of the title compound in crude form as a yellow oil.

1. temperatureAfter cooling
2. temperaturecooling
3. stirringstirring
4. extractionextracted with CH2Cl2
5. dry with materialThe extract was dried over MgSO4
6. distillationthe CH2Cl2 was distilled off