Sodium Hydroxide → 6-(3-Benzyloxycarbonylaminopropionylamino)-hexanoic acid

HRID 249629

反応式

HRID 249629 の反応式
C[O:2][C:3](=[O:25])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH:9][C:10](=[O:24])[CH2:11][CH2:12][NH:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15].[OH-].[Na+]>CO>[CH2:17]([O:16][C:14]([NH:13][CH2:12][CH2:11][C:10]([NH:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:25])=[O:2])=[O:24])=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 692961146-(3-Benzyloxycarbonylaminopropionylamino)-hexanoic acid methyl ester

生成物 1

HCID 692965966-(3-Benzyloxycarbonylaminopropionylamino)-hexanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The compound 36 was prepared using General Procedure A with ester 35 (3.20 g, 9.13 mmol) and an aqueous NaOH solution (1.46 g, 36.53 mmol in 40 mL of H2O) in MeOH (40 mL). Recrystallization from MeOH produced the desired acid 36 in 95% (2.92 g) yield as a white solid. 1H NMR (CDCl3): δ 7.32 (m, 5H, ArH), 6.10 (s, 1H, NH), 5.67 (s, 1H, NH), 5.04 (s, 2H, OCH2Ar), 3.45 (dt, J=6.4, 12.0 Hz, 2H, CH2NHCO), 3.21 (dt, J=6.4, 12.8 Hz, 2H, CH2NHCO), 2.40 (dt, J=6.0, 6.4 Hz, 2H, CH2CO), 2.32 (t, J=7.2 Hz, 2H, CH2CO), 1.61 (m, 2H, CH2), 1.48 (m, 2H, CH2), 1.33 (m, 2H, CH2); ESI-MS m/z 371[M+Cl]−, 359[M+Na]+, 337[M+H]+, 335[M−H]−.

後処理

  1. customThe compound 36 was prepared
  2. customRecrystallization from MeOH

出典と根拠

ORDレコード
ord-54d682a6b1bc444dbeb90db8e1f94eb9
出典データセット
uspto-grants-2011_01
特許番号
US07862807B2

関連ノート

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