Methyl iodide → Ethyl 2-methoxy-6-methylisonicotinate

HRID 249731ノート

反応式

HRID 249731 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([CH3:13])[N:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:14]I>C1(C)C=CC=CC=1>[CH3:14][O:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([CH3:13])[N:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 178469038HCID 178469038、化合物

生成物 1

HCID 45076200Ethyl 2-methoxy-6-methylisonicotinate収率 77.7%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

20.0 g (111.4 mmol) of ethyl 2-hydroxy-6-methylisonicotinate (20a) were suspended in 330 ml of toluene. After addition of 36.54 g (132.5 mmol) of Ag2CO3 and 23.5 g (165.6 mmol) of methyl iodide, the mixture was heated to 100° C. with KPG stirring. After 4 hours, the reaction mixture was allowed to cool to RT and it was filtered through Celite. The filtrate was washed twice with water, dried with Na2SO4 and concentrated, 16.9 g of the title compound being isolated as a yellowish oil.

後処理

  1. temperatureto cool to RT
  2. filtrationit was filtered through Celite
  3. washThe filtrate was washed twice with water
  4. dry with materialdried with Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-fda1b12a7fe14a0dbd517374718a985e
出典データセット
uspto-grants-2011_01
特許番号
US07863269B2

反応ノート

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