Sodium Carbonate → (-)-5-[2-(1-methyl-1H-pyrazol-4-yl)pyrid-5-yl]-1-azabicyclo[3.2.1]octane

HRID 249748

反応式

HRID 249748 の反応式
[CH3:1][N:2]1[CH:6]=[C:5](B(O)O)[CH:4]=[N:3]1.Br[C:11]1[CH:16]=[CH:15][C:14]([C:17]23[CH2:24][N:21]([CH2:22][CH2:23]2)[CH2:20][CH2:19][CH2:18]3)=[CH:13][N:12]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1.C(O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:1][N:2]1[CH:6]=[C:5]([C:11]2[CH:16]=[CH:15][C:14]([C:17]34[CH2:24][N:21]([CH2:22][CH2:23]3)[CH2:20][CH2:19][CH2:18]4)=[CH:13][N:12]=2)[CH:4]=[N:3]1

参加物

7

反応物 3

HCID 10340Sodium CarbonateHCID 112635011-Methyl-1H-pyrazole-4-boronic acidHCID 862593785-(2-Bromopyrid-5-yl)-1-azabicyclo[3.2.1]octane

生成物 1

HCID 16005053(-)-5-[2-(1-methyl-1H-pyrazol-4-yl)pyrid-5-yl]-1-azabicyclo[3.2.1]octane収率 93.2%

試薬・触媒・溶媒 3

HCID 178418397HCID 178418397、化合物触媒HCID 702Ethanol溶媒HCID 1140Toluene溶媒

反応条件

温度
105 °C

実験手順

0.162 g (0.78 mmol) of 1-methyl-4-pyrazolylboronic acid, 0.160 g (0.6 mmol) of (−)-5-(2-bromopyrid-5-yl)-1-azabicyclo[3.2.1]octane (obtained by reacting 5-(2-bromopyrid-5-yl)-1-azabicyclo[3.2.1]octane (−)-hydrobromide (1:1), prepared in step 1.2, with saturated aqueous sodium carbonate solution) are successively introduced into a 10 ml three-necked round-bottomed flask, as a solution in 3 ml of toluene and 0.3 ml of ethanol. 0.035 g (0.03 mmol) of tetrakis(triphenylphosphine)palladium and 0.6 ml of aqueous 2M sodium carbonate solution are then added and the mixture is heated at 105° C. for 18 hours. It is cooled to room temperature, the solvent is evaporated off under reduced pressure and the residue is taken up in 10 ml of chloroform and filtered through diatomaceous earth. The solvent is concentrated under reduced pressure and the residue is purified by chromatography on a column of silica gel, eluting with a mixture of chloroform, methanol and aqueous ammonia in 95/5/0.5 proportions. 0.15 g of (−)-5-[2-(1-methyl-1H-pyrazol-4-yl)pyrid-5-yl]-1-azabicyclo[3.2.1]octane is obtained, and is dissolved in 2 ml of isopropyl alcohol to add 0.196 ml of a 5.7N solution of hydrobromic acid in acetic acid. The crystals obtained are collected by filtration and dried under vacuum.

後処理

  1. temperatureIt is cooled to room temperature
  2. customthe solvent is evaporated off under reduced pressure
  3. filtrationfiltered through diatomaceous earth
  4. concentrationThe solvent is concentrated under reduced pressure
  5. customthe residue is purified by chromatography on a column of silica gel
  6. washeluting with a mixture of chloroform, methanol and aqueous ammonia in 95/5/0.5 proportions

出典と根拠

ORDレコード
ord-b7395c82df684e0da60ee1e48fb735b3
出典データセット
uspto-grants-2011_01
特許番号
US07863290B2

関連ノート

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