(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride → (S)-N-(quinuclidine-8-yl)-2-((2S,6R)-2,6-dimethylmorpholino)benzoxazole-4-carboxamide

HRID 249836

反応式

HRID 249836 の反応式
[CH3:1][C@H:2]1[CH2:7][N:6]([C:8]2[O:9][C:10]3[C:11](=[C:13]([C:17]([OH:19])=O)[CH:14]=[CH:15][CH:16]=3)[N:12]=2)[CH2:5][C@@H:4]([CH3:20])[O:3]1.Cl.Cl.[NH2:23][C@H:24]1[CH:29]2[CH2:30][CH2:31][N:26]([CH2:27][CH2:28]2)[CH2:25]1>>[N:26]12[CH2:25][C@@H:24]([NH:23][C:17]([C:13]3[CH:14]=[CH:15][CH:16]=[C:10]4[O:9][C:8]([N:6]5[CH2:5][C@@H:4]([CH3:20])[O:3][C@@H:2]([CH3:1])[CH2:7]5)=[N:12][C:11]=34)=[O:19])[CH:29]([CH2:30][CH2:31]1)[CH2:28][CH2:27]2

参加物

3

反応物 2

HCID 12494973(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochlorideHCID 668748392-[(2S,6R)-2,6-dimethylmorpholino]benzoxazole-4-carboxylic acid

生成物 1

HCID 66873542(S)-N-(quinuclidine-8-yl)-2-((2S,6R)-2,6-dimethylmorpholino)benzoxazole-4-carboxamide

実験手順

Following general procedure GP-C1, a mixture of 2-[(2S,6R)-2,6-dimethylmorpholino]benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-((2S,6R)-2,6-dimethylmorpholino)benzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

出典と根拠

ORDレコード
ord-f1b8af22538b425c9246877a3c221908
出典データセット
uspto-grants-2011_01
特許番号
US07863271B2

関連ノート

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