Hydrochloric Acid → 4-Amino-5-cyano-2-hydroxybenzoic acid
反応式
[NH2:1][C:2]1[C:12]([C:13]#[N:14])=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[C:4]([OH:15])[CH:3]=1.[OH-].[Na+].Cl>O>[NH2:1][C:2]1[C:12]([C:13]#[N:14])=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:15])[CH:3]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
Ethyl 4-amino-5-cyano-2-hydroxybenzoate (3 g, 14.55 mmol) is treated with 60 ml of a 10% strength sodium hydroxide solution and the mixture is stirred at 50° C. for one hour. After cooling, the reaction solution is acidified with concentrated hydrochloric acid, diluted with water and the precipitate is filtered off with suction. The desired product is obtained after recrystallization from ethanol in 62% yield (1.6 g).
後処理
- temperatureAfter cooling
- filtrationthe precipitate is filtered off with suction
出典と根拠
- ORDレコード
- ord-5010a193e6f04b1990b5337828cc718c
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07863283B2
反応ノート
読み込み中…