2-Amino-4-methylbenzothiazole → N-(4-methylbenzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide

HRID 249999

反応式

HRID 249999 の反応式
[CH3:1][C:2]1[C:7]2[N:8]=[C:9]([NH2:11])[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:12](N1C=CN=C1)([N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1)=[S:13]>C(#N)C>[CH3:1][C:2]1[C:7]2[N:8]=[C:9]([NH:11][C:12]([N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)=[S:13])[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 151322-Amino-4-methylbenzothiazoleHCID 802641,1'-Thiocarbonyldiimidazole

生成物 1

HCID 58088267N-(4-methylbenzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide収率 49%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
50 °C

実験手順

To 4-methylbenzo[d]thiazol-2-amine (1.1 g, 6.7 mmol) in acetonitrile (30 mL) was added 1,1′-thiocarbonyldiimidazole (1.552 g, 8.71 mmol). The reaction mixture was stirred at 50° C. for 18 hours. The reaction was cooled to room temperature and the precipitate was filtered and washed with acetonitrile (2×50 mL). The yellow powder was dried in a vacuum oven (50° C.) for 1 hour to yield N-(4-methylbenzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide (900 mg, 3.28 mmol, 49% yield) and then used in the next step without any further purification or characterization.

後処理

  1. temperatureThe reaction was cooled to room temperature
  2. filtrationthe precipitate was filtered
  3. washwashed with acetonitrile (2×50 mL)
  4. customThe yellow powder was dried in a vacuum oven (50° C.) for 1 hour

出典と根拠

ORDレコード
ord-c961a56e920f41b98c09e6183cab8541
出典データセット
uspto-grants-2011_01
特許番号
US07863291B2

関連ノート

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