Aluminium lithium hydride → 3-Indol-1-yl-3-phenyl-propan-1-ol

HRID 250192ノート

反応式

HRID 250192 の反応式
C[O:2][C:3](=O)[CH2:4][CH:5]([N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[N:12]1([CH:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:4][CH2:3][OH:2])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13]1

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 580885583-Indol-1-yl-3-phenyl-propionic acid methyl ester

生成物 1

HCID 235559373-Indol-1-yl-3-phenyl-propan-1-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 3-indol-1-yl-3-phenyl-propionic acid methyl ester (0.2 g, 0.71 mmol) in THF (5 mL) at 0° C. was added 1M LiAlH4 in THF (0.71 mL), and the mixture was stirred for 0.5 hours at room temperature. The reaction mixture was quenched by the cautious addition of Na2SO4.10H2O and the reaction mixture was stirred for another 1 h at room temperature. The mixture was filtered and the solvent was removed under vacuum. 3-Indol-1-yl-3-phenyl-propan-1-ol was obtained as a clear oil (0.166 g, 92% yield).

後処理

  1. customThe reaction mixture was quenched by the cautious addition of Na2SO4.10H2O
  2. stirringthe reaction mixture was stirred for another 1 h at room temperature
  3. filtrationThe mixture was filtered
  4. customthe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-20521d03cec147bc9bf3d6ddd096cf03
出典データセット
uspto-grants-2011_01
特許番号
US07863305B2

反応ノート

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