Phosphorus tribromide → 4-Bromomethyl-3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazole
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:13]([CH2:14]O)=[C:12]([CH:16]([CH3:18])[CH3:17])[O:11][N:10]=1.P(Br)(Br)[Br:20]>C1COCC1.CCOC(C)=O>[Br:20][CH2:14][C:13]1[C:9]([C:3]2[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][C:4]=2[Cl:8])=[N:10][O:11][C:12]=1[CH:16]([CH3:18])[CH3:17]参加物
5
実験手順
To a solution of [3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazol-4-yl]-methanol (1.14 g, 4 mmol) in THF (20 mL) is added PBr3 (0.76 mL, 8 mmol). The reaction mixture is stirred at reflux for 30 minutes. The reaction mixture is diluted with EtOAc and is washed with 0.2 N HCl. The organic layer is separated, dried (MgSO4), filtered, and concentrated to give the title compound as an oil.
後処理
- temperatureat reflux for 30 minutes
- washis washed with 0.2 N HCl
- customThe organic layer is separated
- dry with materialdried (MgSO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-34863f845a6e4400b25b1ad6be7d4b50
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07863302B2
反応ノート
読み込み中…