Thionyl Chloride → 2,6-Difluoro-3-(propane-1-sulfonylamino)-benzoyl chloride

HRID 250545ノート

反応式

HRID 250545 の反応式
[F:1][C:2]1[C:10]([NH:11][S:12]([CH2:15][CH2:16][CH3:17])(=[O:14])=[O:13])=[CH:9][CH:8]=[C:7]([F:18])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:21])=O>C1(C)C=CC=CC=1>[F:1][C:2]1[C:10]([NH:11][S:12]([CH2:15][CH2:16][CH3:17])(=[O:14])=[O:13])=[CH:9][CH:8]=[C:7]([F:18])[C:3]=1[C:4]([Cl:21])=[O:5]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 461929232,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid

生成物 1

HCID 580868612,6-Difluoro-3-(propane-1-sulfonylamino)-benzoyl chloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To 2,6-difluoro-3-(propane-1-sulfonylamino)-benzoic acid (45, 1.50 g, 5.4 mmol) was added toluene (7.0 mL) and thionyl chloride (15.0 mL, 0.21 mmol). The reaction was heated to reflux for 3 hours. The reaction was concentrated to give crude compound that was used in the next step.

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 3 hours
  3. concentrationThe reaction was concentrated
  4. customto give crude compound that

出典と根拠

ORDレコード
ord-e13a18b9abad4262aaa14dcca7f4b74b
出典データセット
uspto-grants-2011_01
特許番号
US07863288B2

反応ノート

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