6-Chloro-2-fluoro-3-(propane-1-sulfonamido)benzoic acid → 2-Fluoro-3-(propylsulfonamido)benzoic acid

HRID 250550ノート

反応式

HRID 250550 の反応式
Cl[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([F:11])[C:5]([NH:12][S:13]([CH2:16][CH2:17][CH3:18])(=[O:15])=[O:14])=[CH:4][CH:3]=1>CO.[OH-].[OH-].[Pd+2]>[F:11][C:6]1[C:5]([NH:12][S:13]([CH2:16][CH2:17][CH3:18])(=[O:15])=[O:14])=[CH:4][CH:3]=[CH:2][C:7]=1[C:8]([OH:10])=[O:9]

参加物

4

反応物 1

HCID 580875006-Chloro-2-fluoro-3-(propane-1-sulfonamido)benzoic acid

生成物 1

HCID 580865772-Fluoro-3-(propylsulfonamido)benzoic acid

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

To 6-chloro-2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid (115, 0.69 g, 2.3 mmol) in methanol (10 mL) was added 20% palladium hydroxide on carbon (200 mg). The reaction was stirred under hydrogen at 50 psi for 2 hours. The reaction was filtrated and concentrated to give white solid 50 that was used in the next step. MS (ESI) [M−H+]−=260.1.

後処理

  1. filtrationThe reaction was filtrated
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-a26f1d32cc634727b184eae9f21705cb
出典データセット
uspto-grants-2011_01
特許番号
US07863288B2

反応ノート

読み込み中…