5-Chloro-1H-pyrrolo[2,3-b]pyridine → Thiophene-2-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide

HRID 250565

反応式

HRID 250565 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[N:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.FC1C(C=O)=C(F)C=CC=1NS(C(C)C)(=O)=O.[F:28][C:29]1[C:34]([CH:35]=[O:36])=[C:33]([F:37])[CH:32]=[CH:31][C:30]=1[NH:38][S:39]([C:42]1[S:43][CH:44]=[CH:45][CH:46]=1)(=[O:41])=[O:40]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5]([C:35]([C:34]3[C:29]([F:28])=[C:30]([NH:38][S:39]([C:42]4[S:43][CH:44]=[CH:45][CH:46]=4)(=[O:41])=[O:40])[CH:31]=[CH:32][C:33]=3[F:37])=[O:36])=[CH:6][NH:7][C:8]2=[N:9][CH:10]=1

参加物

4

反応物 3

HCID 242292135-Chloro-1H-pyrrolo[2,3-b]pyridineHCID 58086031N-(2,4-difluoro-3-formylphenyl)propane-2-sulfonamideHCID 58086492Thiophene-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide

生成物 1

HCID 58086197Thiophene-2-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide

実験手順

was prepared using the protocol of Steps 3 and 4 of Scheme 17, substituting 5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine 89 with 5-chloro-7-azaindole 80 (see Example 9) and propane-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide 60 with thiophene-2-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide 512 (see Example 21) in Step 3. MS (ESI) [M+H+]+=451.9.

後処理

  1. customwas prepared

出典と根拠

ORDレコード
ord-8de5a0b9dcef4c8c99d30989892eeb95
出典データセット
uspto-grants-2011_01
特許番号
US07863288B2

関連ノート

読み込み中…