Cyclopentylamine → HCID 86067038、化合物

HRID 250725ノート

反応式

HRID 250725 の反応式
[CH3:1][N:2]([O:15][CH3:16])[C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[C:6](F)[CH:5]=1.[CH:17]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18]1.C(#N)C>Cl>[CH3:16][O:15][N:2]([CH3:1])[C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[C:6]([NH:22][CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:5]=1

参加物

5

反応物 3

HCID 2906CyclopentylamineHCID 6342AcetonitrileHCID 577580833-Fluoro-N-methoxy-N-methyl-4-nitrobenzamide

生成物 1

HCID 86067038HCID 86067038、化合物収率 92.1%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

Combine N-[methyl]N-[methoxy]3-fluoro-4-nitrobenzamide (2.3 g, 10 mmol), cyclopentylamine (12.3 mL, 100 mmol) and acetonitrile (50 mL) and stir at room temperature for 6 hours. Dilute with 1N HCl and extract with ethyl acetate. Wash the organic layer sequentially with water and saturated aqueous sodium chloride, then dry over magnesium sulfate. Concentrate under reduced pressure to provide the desired compound as an orange solid (2.7 g, 92%).

後処理

  1. extractionextract with ethyl acetate
  2. washWash the organic layer sequentially with water and saturated aqueous sodium chloride
  3. dry with materialdry over magnesium sulfate
  4. concentrationConcentrate under reduced pressure

出典と根拠

ORDレコード
ord-47f792c7a0824ddcb95f086460f770ef
出典データセット
uspto-grants-2011_01
特許番号
US07863310B2

反応ノート

読み込み中…