Isopropylamine → 5-Bromo-N-isopropyl-2-nitroaniline
反応式
Br[C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH:12]([NH2:15])([CH3:14])[CH3:13]>C(O)CCC>[CH:12]([NH:15][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10])([CH3:14])[CH3:13]参加物
4
実験手順
Heat a mixture of 2,4-dibromonitrobenzene (3.50 g, 12.5 mmol), isopropylamine (4.42 g, 6.40 ml, 74.8 mmol) and n-butanol (20 ml) in a sealed reaction vessel to 117° C. overnight. Cool to room temperature and concentrate under reduced pressure. Partition the residue between ethyl acetate and saturated aqueous sodium chloride, dry the organic layer over sodium sulfate, and concentrate under reduced pressure to provide the desired compound as a yellow solid (3.0 g, 94%).
後処理
- temperatureHeat
- customin a sealed reaction vessel to 117° C. overnight
- concentrationconcentrate under reduced pressure
- customPartition the residue between ethyl acetate and saturated aqueous sodium chloride
- dry with materialdry the organic layer over sodium sulfate
- concentrationconcentrate under reduced pressure
出典と根拠
- ORDレコード
- ord-edab10343770457682b580b83bba213f
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07863310B2
反応ノート
読み込み中…