ethyl(E)-3-(3'-methylaminobiphenyl-4-yl)acrylate → Ethyl 3-(3'-methylaminobiphenyl-4-yl)propanoate
反応式
[CH3:1][NH:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1>CO.[Pd]>[CH3:1][NH:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1参加物
4
実験手順
A solution of 1.7 g (6.0 mmol) of ethyl (E)-3-(3′-methylaminobiphenyl-4-yl)acrylate in 25 ml of methanol is stirred for 12 hours at room temperature in the presence of 300 mg (18% by mass) of 10% palladium-on-charcoal under a hydrogen atmosphere. The palladium is filtered off and the solvent is evaporated off. 1.52 g of ethyl 3-(3′-methylaminobiphenyl-4-yl)propanoate are obtained. Yield=90%