HCID 67272423、化合物 → HCID 20264287、化合物
反応式
[O:1]([C:8]1[C:9]([CH2:14][OH:15])=[N:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)Cl.O=[Mn]=O>[O:1]([C:8]1[C:9]([CH:14]=[O:15])=[N:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
To a solution of (3-phenoxy-pyridin-2-yl)-methanol (0.130 g, 0.646 mmol) in CH2Cl2 (7 mL) was added MnO2 (10 microns, 90+%) (0.645 g, 7.42 mmol) and the resulting black mixture stirred for 24 h. The mixture was filtered through celite and washed with CH2Cl2. The solution was concentrated to give 3-phenoxy-pyridine-2-carbaldehyde as a yellow oil (0.085 g, 67%). 1H NMR (CDCl3) δ 6.97-7.43 (m, 7H), 8.50 (dd, 1H, J=2.8, 1.2 Hz), 10.42 (s, 1H).
後処理
- filtrationThe mixture was filtered through celite
- washwashed with CH2Cl2
- concentrationThe solution was concentrated
出典と根拠
- ORDレコード
- ord-e7e8c832cd634d47a876f87db7ff6834
- 出典データセット
- uspto-grants-2011_01
- 特許番号
- US07863293B2
反応ノート
読み込み中…