3-Methylpyridine-2-carboxaldehyde → Bis-(3-methyl-pyridin-2-ylmethyl)-amine

HRID 251024

反応式

HRID 251024 の反応式
[CH3:1][C:2]1[C:3]([CH2:8][NH2:9])=[N:4][CH:5]=[CH:6][CH:7]=1.[CH3:10][C:11]1[C:12]([CH:17]=O)=[N:13][CH:14]=[CH:15][CH:16]=1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>C(Cl)Cl>[CH3:1][C:2]1[C:3]([CH2:8][NH:9][CH2:17][C:12]2[C:11]([CH3:10])=[CH:16][CH:15]=[CH:14][N:13]=2)=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 15018743-Methylpyridine-2-carboxaldehydeHCID 1514370(3-Methylpyridin-2-yl)methanamineHCID 5049666Sodium triacetoxyborohydride

生成物 1

HCID 45098010Bis-(3-methyl-pyridin-2-ylmethyl)-amine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Using General Procedure B: Reaction of 3-methyl-2-aminomethylpyridine and 3-methyl-2-pyridinecarboxaldehyde in CH2Cl2 with NaBH(OAc)3 gave bis-(3-methyl-pyridin-2-ylmethyl)-amine as a yellow oil. 1H NMR (CDCl3) δ 2.33 s, 6H), 4.06 (s, 4H), 7.08 (dd, 2H, J=9, 6 Hz), 7.42 (dd, 2H, J=9, 3 Hz), 8.41 (d, 2H, J=3 Hz).

出典と根拠

ORDレコード
ord-3c63327a6cd144c2a461ba8a471ee995
出典データセット
uspto-grants-2011_01
特許番号
US07863293B2

関連ノート

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