Sodium borohydride → HCID 67485876、化合物

HRID 251308ノート

反応式

HRID 251308 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH:8]=[O:9])[CH:5]=[C:4]([CH3:10])[C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=1.[BH4-].[Na+]>CO.C(OCC)(=O)C>[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([CH3:10])[C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:18])([F:20])[F:19])=[CH:13][CH:12]=1

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 860853062,6-Dimethyl-4'-trifluoromethyl-biphenyl-4-carbaldehyde

生成物 1

HCID 67485876HCID 67485876、化合物収率 82.6%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To the solution of 2,6-dimethyl-4′-trifluoromethyl-biphenyl-4-carbaldehyde (3.0 g, 10.8 mmol) in MeOH (20 ml) is added NaBH4 (410 mg, 10.8 mmol). The mixture is stirred at room temperature for about 2 h, diluted with ethyl acetate, washed with 1N HCl, water, brine, dried over MgSO4, and concentrated to afford 2.5 g of the titled compound as a white solid. 1H-NMR.

後処理

  1. washwashed with 1N HCl, water, brine
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-7ac35139911a45c99bd9da7d99be2f56
出典データセット
uspto-grants-2011_01
特許番号
US07863329B2

反応ノート

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