Methanimidamide, N,N-diphenyl- → 2-(3-Methoxybenzoyl)-3-phenylamino-acrylonitrile

HRID 251357

反応式

HRID 251357 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[C:6]([CH2:8][C:9]#[N:10])=[O:7].[C:14]1([N:20](C2C=CC=CC=2)[CH:21]=N)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[C:6]([C:8](=[CH:21][NH:20][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:9]#[N:10])=[O:7]

参加物

4

反応物 2

HCID 78296Methanimidamide, N,N-diphenyl-HCID 5847163-(3-Methoxyphenyl)-3-oxopropanenitrile

生成物 1

HCID 670242862-(3-Methoxybenzoyl)-3-phenylamino-acrylonitrile

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

A solution of 3-methoxybenzoylacetonitrile (1.20 g, 68.5 mmol, 1.0 eq) and diphenylformamidine (1.34 g, 68.5 mmol, 1.0 eq) in 25 mL of toluene was stirred at room temperature for 2h then heated to 100° C. overnight. The solution was cooled and diluted with hexanes. The resulting solid was filtered and dried to provide the desired product. HPLC (4 minute 10-90 gradient) tR 3.05 min; MS m/z 279.2 [M+H]+.

後処理

  1. temperatureThe solution was cooled
  2. filtrationThe resulting solid was filtered
  3. customdried

出典と根拠

ORDレコード
ord-6dd22fdfc3474aa3af65bf73b381ac40
出典データセット
uspto-grants-2011_01
特許番号
US07863314B2

関連ノート

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