Sodium Hydroxide → Quetiapine

HRID 251397ノート

反応式

HRID 251397 の反応式
C([O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[S:20][C:19]3[CH:27]=[CH:28][CH:29]=[CH:30][C:18]=3[N:17]=2)[CH2:12][CH2:11]1)(=O)C.[OH-].[Na+]>C(O)C>[CH:24]1[CH:25]=[CH:26][C:21]2[S:20][C:19]3[CH:27]=[CH:28][CH:29]=[CH:30][C:18]=3[N:17]=[C:16]([N:13]3[CH2:14][CH2:15][N:10]([CH2:9][CH2:8][O:7][CH2:6][CH2:5][OH:4])[CH2:11][CH2:12]3)[C:22]=2[CH:23]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 11487114Quetiapine acetate

生成物 1

HCID 5002Quetiapine収率 98.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The residue of 11-(4-[2-(2-acetyloxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine (7.8 g) was dissolved in ethanol (50 ml) and 1M NaOH solution (55 ml) was added. The mixture was stirred at room temperature for 30 min. The product was extracted into toluene (2×100 ml). Evaporation of the toluene phase gave quetiapine base (6.9 g).

後処理

  1. extractionThe product was extracted into toluene (2×100 ml)
  2. customEvaporation of the toluene phase

出典と根拠

ORDレコード
ord-a5210979d7f94179863f210cad5b3ea0
出典データセット
uspto-grants-2011_01
特許番号
US07863441B2

反応ノート

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