Trifluoroacetic acid → 4-(2,6-Difluorophenyl)-4-oxobutyric acid

HRID 251543

反応式

HRID 251543 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9](=[O:19])[CH2:10][CH2:11][C:12]([O:14]C(C)(C)C)=[O:13].FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9](=[O:19])[CH2:10][CH2:11][C:12]([OH:14])=[O:13]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 21964547tert-Butyl 4-(2,6-difluorophenyl)-4-oxobutyrate

生成物 1

HCID 219645164-(2,6-Difluorophenyl)-4-oxobutyric acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of tert-Butyl 4-(2,6-difluorophenyl)-4-oxobutyrate (Step A, 9.52 g, 35.2 mmol) in dichloromethane (30 ml) was treated with trifluoroacetic acid (20 ml). The mixture was stirred at ambient temperature for 3 hours and concentrated. The purification was done by flash chromatography on silica gel column (chloroform:methanol, 95:5 spiked with acetic acid) to provide the title compound as a white solid.

後処理

  1. concentrationconcentrated
  2. customThe purification

出典と根拠

ORDレコード
ord-74b57c305d0d48bfa8c19a4da48d300d
出典データセット
uspto-grants-2011_01
特許番号
US07863475B2

関連ノート

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